England interim coach Stuart Lancaster has made four changes to the line-up to face Wales in their Six Nations clash on Saturday.
Manu Tuilagi returns for the first time since the World Cup, while Geoff Parling, Ben Morgan and Lee Dickson have been handed their first starts for England, who are 6/4 with bet365 to win their first home game of the campaign.
Owen Farrell moves to fly-half with Charlie Hodgson out of action with a finger injury. Toby Flood is on the bench alongside Phil Dowson and Ben Youngs, while Tom Palmer left the squad earlier this week.
“It’s our first home game of the RBS Six Nations which we are really excited about and we are sure the crowd will get behind us just as the travelling supporters have done in Scotland and Italy,” said Lancaster.
“Playing at Twickenham makes it extra special for us and I know we will get all the encouragement we need.”