Head coach Warren Gatland is backing Wales, 1/2 with bookmaker to win the Grand Slam, to be ruthless when they take on Italy at the Millennium Stadium.
A win over the Azzurri will set up a final-day showdown with France in the Welsh capital, with Gatland confident that his side will not be distracted by the prospect of a third Grand Slam in eight years.
Gatland said: “We are back at the Millennium Stadium and we need to refocus sharply after our Triple Crown triumph at Twickenham.
“Italy will be hoping to find us complacent and with one eye on the French game, but nothing less than victory on Saturday will be accepted.
“All of that leaves the players themselves brimming with ruthless intent.”
Wales will be missing injured captain Sam Warburton when they run out against Italy, with prop Gethin Jones leading the side.